Click here to watch the UKCCRs 2026 results of the oseltamivir intervention in critically ill influenza patients

ICU

Decorative dots

We are delighted to share with you that REMAP-CAP has been selected by the NIHR as the platform trial to evaluate therapeutic interventions for influenza! It is great that they have recognised all the fantastic work you have helped achieve with COVID-19 and now we can continue to use our exciting trial design to study flu in a wider population. Please see the domains available to ICU patients below. To access the training material for the domains, please click on the grey icon.

Click here to randomise a patient

Severe

Moderate

Severe disease state is defined as patients who receive organ failure support in an ICU.

Moderate disease state is defined as:

  • not being admitted to an ICU, or
  • admitted to an ICU but not receiving organ failure support

A
ANTIBIOTICS
NON-PANDEMIC CAP
PANDEMIC
A.1 – Ceftriaxone + Macrolide
A.2 – Moxifloxacin or Levofloxacin
A.3 – Piperacillin‐Tazobactam + Macrolide
A.4 – Amoxicillin‐Clavulanate + Macrolide

M
Macrolide Duration
NON-PANDEMIC CAP
PANDEMIC
M.1 – Standard course macrolide
M.2 – Extended course macrolide

C
Corticosteroid
NON-PANDEMIC CAP / FLU
PANDEMIC
C.1 – No corticosteroid
C.3 – Shock‐dependent hydrocortisone
C.5 – Fixed‐course dexamethasone

I
Influenza Antiviral
NON-PANDEMIC CAP / FLU
PANDEMIC
I.1 – No antiviral for influenza
I.2 – Oseltamivir 5 days
I.3 – Oseltamivir 10 days
I.4 – Baloxavir on days 1 and 4 *
I.5 – 5 days Oseltamivir + Baloxavir on days 1 & 4 *
I.6 – 10 days Oseltamivir + Baloxavir on days 1 & 4 *

P
Immunoglobulin
NON-PANDEMIC CAP
PANDEMIC
P.1 – No immunoglobulin for COVID‐19
P.2 – High‐titer convalescent plasma

N
Immune Modulation
NON-PANDEMIC CAP / FLU
PANDEMIC
N.1 – No immune modulation
N.2 – Tocilizumab
N.3 – Baricitinib

Influenza Swabs

To place an order for swabs please contact the team at ukremap-cap@icnarc.org 
 
Please do take swabs on day 1, 3 and 7 for randomised patients who are flu positive and post these back to the address included on the return safe box.

Before posting the samples to us, please enter the details for the samples on spinnaker and complete the swab tracker found in Documentation > 10. Swabs.
Completed your training?

Fill in the form and send the confirmation email to ukremap-cap@icnarc.org